06855770 is referenced by 56 patents and cites 25 patents.

A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X—(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.

Title
Drug delivery compositions and medical devices containing block copolymer
Application Number
10/319802
Publication Number
6855770 (B2)
Application Date
December 13, 2002
Publication Date
February 15, 2005
Inventor
Kalpana Kamath
Natick
MA, US
Marlene Schwarz
Newton
MA, US
Sepideh Nott
Weston
MA, US
Leonard Pinchuk
Miami
FL, US
Agent
David B Bonham Esq
Mayer Fortkort & Williams PC
Assignee
SciMed Life Systems
MN, US
IPC
A61L 027/00
A61K 009/22
C08L 023/04
C08L 023/00
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