06777395 is referenced by 142 patents and cites 23 patents.

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

Title
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus
Application Number
10/52318
Publication Number
6777395 (B2)
Application Date
January 18, 2002
Publication Date
August 17, 2004
Inventor
David B Olsen
Lansdale
PA, US
Malcolm Maccoss
Freehold
NJ, US
Steven S Carroll
Yardley
PA, US
Phillip Dan Cook
Fallbrook
CA, US
Quanlai Song
San Marcos
CA, US
Marija Prhavc
Carlsbad
CA, US
Thazha P Prakash
Carlsbad
CA, US
Anne B Eldrup
Encinitas
CA, US
Neelima Bhat
Carlsbad
CA, US
Balkrishen Bhat
Carlsbad
CA, US
Agent
Melvin Winokur
US
Philippe L Durette
US
Assignee
Isis Pharmaceuticals
CA, US
Merck & Co
NJ, US
IPC
A61K 31/70
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