06770643 is referenced by 36 patents and cites 42 patents.

The invention is directed to compositions containing physiologically active compounds of general formula (I):

wherein R

1

is aryl or heteroaryl; R

2

represents hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, —Z

1

R

8

, —C(═O)—NY

3

Y

4

, —CO

2

R

8

, —NY

3

Y

4

, —N(R

6

)—C(═O)—R

7

, —N(R

6

)—C(═O)—NY

3

Y

4

, —N(R

6

)—C(═O)—OR

7

, —N(R

6

)—SO

2

—R

7

, —N(R

6

)—SO

2

—NY

3

Y

4

and one or more halogen a toms ; R

3

represents hydrogen, aryl, cyano, halo, heteroaryl, lower alkyl, —C(═O)—OR

5

or —C(═O)—NY

3

Y; and X

1

represents N, CH, C-halo, C—CN, C—R

7

, C—NY

3

Y

4

, C—OH, C—Z

2

R

7

, C—C(═O)—OR

5

, C—C(═O)—NY

3

Y

4

, C—N(R

8

)—C(═O)—R

7

, C—SO

2

—NY

3

Y

4

, C—N(R

8

)—SO

2

—R

7

, C-alkenyl, C-alkynyl or C—NO

2

; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I).

Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit protein kinases.

Title
Azaindoles
Application Number
10/178667
Publication Number
6770643 (B2)
Application Date
June 24, 2002
Publication Date
August 3, 2004
Inventor
Christopher Edlin
Newark
US
Stephanie D Deprets
Paris
US
Shelley Amendola
Bedminster
NJ, US
Andrew D Morley
Macclesfield
US
Justine Y Q Lai
Epping
US
Tahir N Majid
Hoboken
NJ, US
Paul J Cox
Millington
NJ, US
Agent
George G Wang
US
Assignee
Aventis Pharma
US
IPC
C07D 471/04
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