06743211 is referenced by 577 patents and cites 13 patents.

Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to (1) limit the elasticity, (2) adapt to the elasticity, (3) utilize alternate ways of creating the holes for the microneedles to penetrate the biological barrier, other than the simply direct pressure of the microneedle substrate to the barrier surface, or (4) any combination of these methods. In preferred embodiments for limiting the elasticity of skin, the microneedle device includes features suitable for stretching, pulling, or pinching the skin to present a more rigid, less deformable, surface in the area to which the microneedles are applied (i.e. penetrate). In a preferred embodiments for adapting the device to the elasticity of skin, the device comprising one or more extensions interposed between the substrate and the base end of at least a portion of the microneedles.

Title
Devices and methods for enhanced microneedle penetration of biological barriers
Application Number
9/448107
Publication Number
6743211 (B1)
Application Date
November 23, 1999
Publication Date
June 1, 2004
Inventor
Thomas Jackson
La Jolla
CA, US
Donald E Ackley
Cardiff
CA, US
Devin V McAllister
Holley
NY, US
Sebastien Henry
Smyrna
GA, US
Mark G Allen
Atlanta
GA, US
Mark R Prausnitz
Decatur
GA, US
Agent
Ropes & Gray
US
Assignee
Georgia Tech Research Corporation
GA, US
IPC
A61M 5/00
View Original Source