06727349 is referenced by 29 patents and cites 8 patents.

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

Title
Recombinant anti-CCR2 antibodies and methods of use therefor
Application Number
9/497625
Publication Number
6727349 (B1)
Application Date
February 3, 2000
Publication Date
April 27, 2004
Inventor
Theresa O&apos Keefe
Waltham
MA, US
Siobhan H O&apos Brien
Finchley
US
S Tarran Jones
Radlett
US
Walter Newman
Boston
MA, US
Christopher Horvath
Taunton
MA, US
Gregory J LaRosa
Newton
MA, US
Agent
Hamilton Brook Smith & Reynolds P C
US
Assignee
Millennium Pharmaceuticals
MA, US
IPC
C07K 16/00
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