06727256 is referenced by 61 patents and cites 29 patents.

Substituted heteroaromatic compounds of formula (I), wherein X is N or CH; Y is CR

1

and V is N; or Y is N and V is CR

1

; or Y is CR

1

and V is CR

2

; or Y is CR

2

and V is CR

1

; R

1

represents a group CH

3

SO

2

CH

2

CH

2

NHCH

2

—Ar—, wherein Ar is selected from phenyl, furan, thiophene, pyrrole and thiazole, each of which may optionally be substituted by one or two halo, C

1-4

alkyl or C

1-4

alkoxy groups; R

2

is selected from the group comprising hydrogen, halo, hydroxy, C

1-4

alkyl, C

1-4

alkoxy, C

1-4

alkylamino and di[C

1-4

alkyl]amino; U represents a phenyl, pyridyl, 3H-imidazolyl, indolyl, isoindolyl, indolinyl, isoindolinyl, 1H-indazolyl, 2,3-dihydro-1H-indazolyl, 1H-benzimidazolyl, 2,3-dihydro-1H-benzimidazolyl or 1H-benzotriazolyl group, substituted by an R

3

group and optionally substituted by at least one independently selected R

4

group; R

3

is selected from a group comprising benzyl, halo-, dihalo- and trihalobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, phenoxy, benzyloxy, halo-, dihalo- and trihalobenzyloxy and benzenesulphonyl, or R

3

represents trihalomethylbenzyl or trihalomethylbenzyloxy; or R

3

represents a group of formula (a) wherein each R

5

is independently selected from halogen, C

1-4

alkyl, C

1-4

alkoxy; and n is 0 to 3; each R

4

is independently hydroxy, halogen, C

1-4

alkyl, C

2-4

alkenyl, C

2-4

alkynyl, C

1-4

alkoxy, amino, C

1-4

alkylamino, di[C

1-4

alkyl]amino, C

1-4

alkylthio, C

1-4

alkylsulphinyl, C

1-4

alkylsulphonyl, C

1-4

alkylcarbonyl, carboxy, carbamoyl, C

1-4

alkoxycarbonyl, C

1-4

alkanoylamino, N-(C

1-4

alkyl)carbamoyl, N,N-di(C

1-4

alkyl)carbamoyl, cyano, nitro and trifluoromethyl; and salts and solvates thereof, are disclosed, as are methods for their preparation, pharmaceutical compositions containing them and their use in medicine.

Title
Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
Application Number
9/582746
Publication Number
6727256 (B1)
Application Date
June 30, 2000
Publication Date
April 27, 2004
Inventor
Kathryn Jane Smith
Bishop's Stortford
US
Karen Elizabeth Lackey
Hillsborough
NC, US
Stephen Barry Guntrip
Hertford
US
George Stuart Cockerill
Bedford
US
Malcolm Clive Carter
Ware
US
Agent
John L Lemanowicz
US
Assignee
SmithKline Beecham Corporation
PA, US
IPC
A61K 31/505
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