06713089 is referenced by 42 patents and cites 2 patents.

The present invention relates to an oral modified release pharmaceutical composition for the administration of a therapeutically and/or prophylactically effective amount of an active substance (a drug substance), to obtain a relatively fast or quick onset of the therapeutic and/or prophylactic effect. The drug substances contained in a modified release pharmaceutical composition according to the invention are suitably a drug substance which has a pKa value below about 5, such as in a range of from about 4 to about 5. The composition is based on a powder comprising a therapeutically and/or prophylactically active substance and has such a particle size that: when the powder is subjected to a sieve analysis, then at least about 90% w/w of the particles pass through a 180 micron sieve, and when the powder is contacted with an aqueous medium to form a particulate composition, which as such a particle size that when the particulate composition is subjected to a sieve analysis, then at least about 50% w/w of the particles passes through a 180 micron sieve. Further more, the composition, when tested in accordance with the dissolution method (I) defines herein, employing 0.07 HCl as dissolution medium, release at least about 50% w/w of the active substance within the first 20 minutes of the test.

Title
Quick release pharmaceutical compositions of drug substances
Application Number
9/786864
Publication Number
6713089 (B1)
Application Date
July 10, 2001
Publication Date
March 30, 2004
Inventor
Shigeru Itai
Ageo
US
Hermann Ruckendorfer
Reichenthal
US
Niels Gjørløv Hansen
Fredericksberg
US
Poul Bertelsen
Vanløse
US
Agent
Edwards & Angell
US
Agent
Christine C O&apos Day
US
Peter F Corless
US
Assignee
Nycomed Danmark
US
IPC
A61K 9/14
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