06701176 is referenced by 232 patents and cites 7 patents.

A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

Title
Magnetic-resonance-guided imaging, electrophysiology, and ablation
Application Number
9/428990
Publication Number
6701176 (B1)
Application Date
October 29, 1999
Publication Date
March 2, 2004
Inventor
Joao Lima
Timonium
MD, US
Hugh Calkins
Balt
MD, US
Albert Lardo
Baldwin
MD, US
Elliot R McVeigh
Potomac
MD, US
Ergin Atalar
Columbia
MD, US
Ronald D Berger
Baltimore
MD, US
Henry R Halperin
Baltimore
MD, US
Agent
Foley Hoag
US
Assignee
Johns Hopkins University School of Medicine
MD, US
IPC
A61B 5/055
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