06689563 is referenced by 13 patents and cites 8 patents.

The systems and methods described herein relate to nucleic acid probes comprising a a pattern of universal and designate nucleotides, or ‘gapped’ probes, and the use of sets of gapped probes in sequencing by hybridization to determine the sequence of nucleic acid sequences. The inclusion of universal nucleotides in the probes allows for efficient and rapid sequencing of longer nucleotide sequences than can be sequenced using traditional probes. The systems and methods described herein also relate to apparatus for sequencing nucleic acids which include gapped probes, as well as computer systems capable of analyzing data generated using gapped probes in such apparatus.

Title
System and methods for sequencing by hybridization
Application Number
9/735776
Publication Number
6689563 (B2)
Application Date
December 13, 2000
Publication Date
February 10, 2004
Inventor
Eliezer Upfal
Providence
RI, US
Franco P Preparata
Providence
RI, US
Agent
Ropes & Gray
US
Agent
John D Quisel
US
Matthew P Vincent
US
Assignee
Brown University Research Foundation
RI, US
IPC
C12Q 1/68
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