06687522 is referenced by 216 patents and cites 7 patents.

A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more sampling chambers that functions alternatively as both an anode and cathode during the course of the method; reversing the polarity to cause direct current to flow in second direction opposite the first direction; and analyzing the sampling chamber or chambers for the concentration of a substance or a substance metabolite. There is also provided a device for sampling of a substance from an organism on continuously or intermittently using alternating polarity method based on the application of low intensity electric fields of alternating polarity across the skin (iontophoresis) to enhance the transport of a substance (such as glucose, lactic acid, pyruvic acid, and the like) from body tissues to a sampling chamber. The device comprises an electrical power supply; a transdermal system that contains one or more sampling chambers that function as both anode and cathode during the course of sampling; a means to alternates or reverses the polarity during the iontophoretic sampling; and means for analyzing for the concentration of a substance or a substance metabolite.

Title
Device for sample of substances using alternating polarity
Application Number
9/893916
Publication Number
6687522 (B2)
Application Date
June 28, 2001
Publication Date
February 3, 2004
Inventor
Janet Tamada
Belmont
CA, US
Agent
Cary R Fabian
US
Barbara G McClung
US
Assignee
Cygnus
CA, US
IPC
A61B 5/05
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