06673611 is referenced by 68 patents and cites 22 patents.

This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.

Title
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
Application Number
9/866316
Publication Number
6673611 (B2)
Application Date
May 25, 2001
Publication Date
January 6, 2004
Inventor
Jasenka Matulic Adamic
Boulder
CO, US
Peter Haeberli
Berthoud
CO, US
Tod Woolf
Sudbury
MA, US
Thale Jarvis
Boulder
CO, US
Michael Zwick
Madison
WI, US
Mark Reynolds
Pleasanton
CA, US
Laurent Bellon
Frederick
MD, US
Alexander Karpeisky
Lafayette
CO, US
James McSwiggen
Boulder
CO, US
Leonid Beigelman
Longmont
CO, US
James Thompson
Lafayette
CO, US
Agent
McDonnell Boehnen Hulbert & Berghoff
US
Assignee
Sirna Therapeutics
CO, US
IPC
C12Q 1/68
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