06657103 is referenced by 51 patents and cites 15 patents.

Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.

Title
Human antibodies derived from immunized xenomice
Application Number
8/923138
Publication Number
6657103 (B1)
Application Date
September 4, 1997
Publication Date
December 2, 2003
Inventor
Daniel J Capon
Hillsborough
CA, US
Daniel G Brenner
San Mateo
CA, US
Sue Klapholz
Stanford
CA, US
Aya Jakobovits
Menlo Park
CA, US
Raju Kucherlapati
Darien
CT, US
Agent
Fish & Neave
US
Agent
Jane T Gunnison
US
James F Haley Jr
US
Assignee
Abgenix
CA, US
IPC
C12P 21/00
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