06645731 is referenced by 106 patents and cites 4 patents.

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater sensitivity than conventional PCR or immunohistochemistry by 1-2 orders of magnitude. In addition, the assay facilitates the biological characterization and staging of carcinoma cells.

Title
Methods and reagents for the rapid and efficient isolation of circulating cancer cells
Application Number
9/904472
Publication Number
6645731 (B2)
Application Date
July 13, 2001
Publication Date
November 11, 2003
Inventor
Paul A Liberti
Huntingdon Valley
PA, US
Emilian V Racila
Dallas
TX, US
Jonathan W Uhr
Dallas
TX, US
Galla Chandra Rao
Princeton
NJ, US
Leon W M M Terstappen
Huntington Valley
PA, US
Agent
Dann Dorfman Herrell and Skillman
US
Assignee
Immunivest Corporation
DE, US
IPC
G01N 33/574
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