06627422 is referenced by 28 patents and cites 8 patents.

A device is provided containing cells or tissue distributed on a filamentous cell-supporting matrix which is encapsulated by a semi-permeable membrane which can be immunoisolatory. The matrix may be formed of a plurality of monofilaments twisted into yarn that is in non-woven strands, or of the monofilaments or yarn woven into a mesh. Configurations of the matrix include a hollow cylinder, tube, solid cylinder or cord. A coating of extracellular matrix molecules may be on the matrix, or the matrix may be treated with plasma irradiation to enhance cell adhesion. The device can be made by inserting the matrix in a hollow membrane tube, injecting cells or tissue into the tube and sealing ends of the tube. The device is particularly useful for implantation into a mammalian host to provide therapy resulting from a biologically active molecule produced by the cells and tissue.

Title
Device containing cell-supporting yarn matrix encapsulated in a semi-permeable membrane
Application Number
9/673339
Publication Number
6627422 (B1)
Application Date
December 21, 2000
Publication Date
September 30, 2003
Inventor
David Rhein
Cambridge
MA, US
Rebecca Li
Bedford
MA, US
Agent
Mintz Levin Cohn Ferris Glovsky and Popeo P C
US
Agent
Ivor R Elrifi Esq
US
Christina V Karnakis Esq
US
Assignee
Neurotech
US
IPC
C12N 11/04
View Original Source