06603008 is referenced by 160 patents and cites 16 patents.

This invention relates to a compound of the formula:

or a pharmaceutically acceptable salt thereof, wherein A and R

1

are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R

2

is NH

2

; R

3

and R

4

are each hydrogen, halo, (C

1

-C

4

)alkyl optionally substituted with halo and the like; and X

1

to X

4

are each hydrogen, halo, hydroxy, (C

1

-C

4

)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.

Title
Sulfamoylheleroaryl pyrazole compounds as anti-inflammatory/analgesic agents
Application Number
9/723661
Publication Number
6603008 (B1)
Application Date
November 28, 2000
Publication Date
August 5, 2003
Inventor
Kiyoshi Kawamura
Aichi
US
Kazuo Ando
Aichi-Ken
US
Agent
Lance Y Liu
US
Gregg C Benson
US
Peter C Richardson
US
Assignee
Pfizer
NY, US
IPC
C07D 401/04
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