06566367 is referenced by 57 patents and cites 5 patents.

Substituted spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders (e.g., eating disorders such as obesity or bulimia, psychiatric disorders, diabetes and cardiovascular disorders such as hypertension) in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such compounds for detecting NPY5 receptors.

Title
Spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines
Application Number
10/13846
Publication Number
6566367 (B2)
Application Date
December 11, 2001
Publication Date
May 20, 2003
Inventor
Marlys Hammond
Salem
CT, US
Richard Louis Elliott
East Lyme
CT, US
Xiaozhang Zheng
Branford
CT, US
Jennifer Tran
Guilford
CT, US
Alan Hutchison
Madison
CT, US
Stéphane De Lombaert
Madison
CT, US
James William Darrow
Wallingford
CT, US
Harry L Brielmann
Guilford
CT, US
Charles A Blum
Westbrook
CT, US
Rajagopal Bakthavatchalam
Branford
CT, US
Agent
Ladas & Parry
US
Assignee
Neurogen Corporation
CT, US
Pfizer
NY, US
IPC
C07D 471/10
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