06541116 is referenced by 69 patents.

A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a top coat having a therapeutic, diagnostic or hydrophilic agent, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of an agent, a grafting component, and salt. In one embodiment, the therapeutic agent is superoxide dismutase or a superoxide dismutase mimic. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device such as a stent coated with a polymeric primer or without a primer.

Title
Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device
Application Number
9/827977
Publication Number
6541116 (B2)
Application Date
April 6, 2001
Publication Date
April 1, 2003
Inventor
Stephen J Bigus
San Jose
CA, US
Deborah L Kilpatrick
Mountain View
CA, US
Christopher J Buchko
Redwood City
CA, US
Eugene T Michal
San Francisco
CA, US
Agent
Filwider Patton Lee & Utecht
US
Assignee
Advanced Cardiovascular Systems
CA, US
IPC
B32B 7/04
View Original Source