06534012 is referenced by 55 patents and cites 3 patents.

An apparatus for varying localized absorption and scattering coefficients at a tissue measurement site in a controlled and reproducible manner during optical sampling of a tissue volume by controlling the pressure applied to a tissue measurement site by a spectroscopic analyzer allows applied pressure to be maintained at a constant level, or the applied pressure may be varied in a controlled, reproducible manner as a function of time. A rest for receiving a body part holds the body part in a fixed position and at a fixed elevation. A mechanical system advances a fiber optic probe until it makes contact with the body part with a constant amount of pressure. The applied force is supplied by a counterweight on a single arm balance. A temperature control allows the temperature of the fiber optic probe to be equilibrated with the temperature in the immediate vicinity of the tissue measurement site. Alternate embodiments allow the fiber optic probe to be brought into direct contact with the tissue measurement site, and displaced a known distance into the tissue. The invention is also embodied as a method in which the absorption and scattering coefficients for successive spectral measurements are calculated to determine optimum depth of penetration for detection of a target analyte.

Title
Apparatus and method for reproducibly modifying localized absorption and scattering coefficients at a tissue measurement site during optical sampling
Application Number
9/631440
Publication Number
6534012 (B1)
Application Date
August 2, 2000
Publication Date
March 18, 2003
Inventor
Roxanne E Abul Haj
Mesa
AZ, US
N Alan Abul Haj
Mesa
AZ, US
George Acosta
Phoenix
AZ, US
Kevin H Hazen
Phoenix
AZ, US
Agent
Glenn Patent Group
US
Agent
Christopher Peil
US
Michael A Glenn
US
Assignee
Sensys Medical
AZ, US
IPC
G01N 21/47
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