06509015 is referenced by 175 patents and cites 15 patents.

Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor &agr; (hTNF&agr;) are disclosed. These antibodies have high affinity for hTNF&agr; (e.g., K

d

=10

−8

M or less), a slow off rate for hTNF&agr; dissociation (e.g., K

off

=10

−3

sec

−1

or less) and neutralize hTNF&agr; activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNF&agr; and for inhibiting hTNF&agr; activity, e.g., in a human subject suffering from a disorder in which hTNF&agr; activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

Title
Human antibodies that bind human TNFa
Application Number
9/540018
Publication Number
6509015 (B1)
Application Date
March 31, 2000
Publication Date
January 21, 2003
Inventor
Alison J Wilton
Cambridge
US
Michael White
Framingham
MA, US
Tristan J Vaughan
Cambridge
US
David Schoenhaut
Clifton
NJ, US
Paul Sakorafas
Shrewsbury
MA, US
Andrew J Roberts
Cambridge
US
Brian T McGuinness
Cambridge
US
John A Mankovich
Andover
MA, US
Boris Labkovsky
Framingham
MA, US
Zehra Kaymakcalan
Westboro
MA, US
Hendricus R J M Hoogenboom
Hasselt
US
Deborah J Allen
London
US
Jochen G Salfeld
North Grafton
MA, US
Agent
Lahive & Cockfield
US
Agent
Elizabeth A Hanley Esq
US
Giulio A DeConti Jr Esq
US
Assignee
BASF Aktiengesellschaft
US
IPC
A61K 39/395
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