06503480 is referenced by 74 patents and cites 7 patents.

Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm

3

and a mass mean diameter between 5 &mgr;m and 30 &mgr;m. The particles may be formed of biodegradable mat as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung. The aerodynamically light particles optionally can incorporate a therapeutic or diagnostic agent, and may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of incrorporated agents.

Title
Aerodynamically light particles for pulmonary drug delivery
Application Number
9/194068
Publication Number
6503480 (B1)
Application Date
April 8, 1999
Publication Date
January 7, 2003
Inventor
Robert S Langer
Newton
MA, US
Abdell Aziz Ben Jebria
State College
PA, US
Justin Hanes
Baltimore
MD, US
Noah Lotan
Haifa
US
Jeffrey S Hrkach
Somerville
MA, US
Giovannia Caponetti
Piacenza
US
David A Edwards
Boston
MA, US
Agent
Hamilton Brook Smith & Reynolds P C
US
Assignee
The Penn State Research Foundation
PA, US
Massachusetts Institute of Technology
MA, US
IPC
A61K 9/12
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