06497729 is referenced by 231 patents and cites 6 patents.

A tissue/implant interface, comprising an implant and a bioactive polymer layer adjacent at least a portion of the outer surface of the implant, wherein the polymer layer contains at least one tissue response modifier covalently attached to the polymer layer or entrapped within the polymer layer in a quantity effective to control the tissue response at the site of implantation. Preferably, the at least one tissue response modifier controls inflammation, fibrosis, and/or neovascularization. Exemplary tissue response modifiers include, but are not limited to, steroidal and non-steroidal anti-inflammatory agents, anti-fibrotic agents, anti-proliferative agents, cytokines, cytokine inhibitors, neutralizing antibodies, adhesive ligands, and combinations thereof. Use of the various combinations of tissue response modifiers with bioactive polymers provides a simple, flexible and effective means to control the implant/tissue interphase, improving implant lifetime and function.

Title
Implant coating for control of tissue/implant interactions
Application Number
9/443857
Publication Number
6497729 (B1)
Application Date
November 19, 1999
Publication Date
December 24, 2002
Inventor
Samuel Huang
Bloomfield
CT, US
Fotios Papadimitrakopoulos
Coventry
CT, US
Jeffrey Koberstein
Mansfield
CT, US
Diane Burgess
Storrs
CT, US
Donald Kreutzer
Avon
CT, US
Francis Moussy
Farmington
CT, US
Agent
Cantor Colburn
US
Assignee
The University of Connecticut
CT, US
IPC
A61F 2/02
View Original Source