06489346 is referenced by 64 patents and cites 150 patents.

There is provided a solid pharmaceutical composition in a dosage form that is not enteric-coated, having active ingredients including a non-enteric coated proton pump inhibitor and at least one buffering agent. The proton pump inhibitor is omeprazole, lansoprazole, rabeprazole, esomeprazole, pantoprazole, pariprazole, and leminoprazole, or an enantiomer, isomer, derivative, free base, or salt thereof, in an amount of approximately 5 mg to approximately 300 mg; and the buffering agent is in an amount of approximately 0.1 mEq to approximately 2.5 mEq per mg of proton pump inhibitor. The dosage form includes a suspension tablet, a chewable tablet, an effervescent powder, or an effervescent tablet. Also provided is a method for treating an acid-related gastrointestinal disorder in a subject in need thereof by administering to the subject a solid pharmaceutical composition.

Title
Substituted benzimidazole dosage forms and method of using same
Application Number
9/481207
Publication Number
6489346 (B1)
Application Date
January 11, 2000
Publication Date
December 3, 2002
Inventor
Jeffrey Owen Phillips
Ashland
MO, US
Agent
Mayer Brown Rowe & Maw
US
Agent
Thomas R Stiebel
US
Joseph A Mahoney
US
Assignee
The Curators of the University of Missouri
MO, US
IPC
C07D 401/12
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