06476038 is referenced by 3 patents and cites 1 patents.

Disclosed are compounds of the formula:

where R

1

, R

2

, R

3

, R

4

, R

5

, R

6

, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided.

Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.

Title
Amino substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines
Application Number
9/676972
Publication Number
6476038 (B1)
Application Date
September 29, 2000
Publication Date
November 5, 2002
Inventor
Philip Albert Carpino
Groton
CT, US
David Andrew Griffith
Old Saybrook
CT, US
Mark Giangiordano
Branford
CT, US
Jennifer Tran
Guilford
CT, US
Charles Blum
Westbrook
CT, US
St├ęphane De Lombaert
Madison
CT, US
James W Darrow
Wallingford
CT, US
Agent
Ladas & Parry
US
Assignee
Pfizer
NY, US
Neurogen Corporation
CT, US
IPC
C07D 487/04
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