06475363 is referenced by 26 patents.

A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

Title
Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
Application Number
9/477585
Publication Number
6475363 (B1)
Application Date
January 4, 2000
Publication Date
November 5, 2002
Inventor
J Michael Ramsey
Knoxville
TN, US
Agent
Dann Dorfman Herrell and Skillman P C
US
Assignee
UT Battelle
TN, US
IPC
G01N 27/447
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