06458813 is referenced by 13 patents and cites 40 patents.

Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Title
Substituted pyridine compounds and methods of use
Application Number
9/932281
Publication Number
6458813 (B1)
Application Date
August 17, 2001
Publication Date
October 1, 2002
Inventor
John A Josey
Longmont
CO, US
Stephen T Schlachter
Boulder
CO, US
Nathan B Mantlo
Lafayette
CO, US
Agent
Steven M Odre
US
Frank S Ungemach
US
Richard V Person
US
Assignee
Amgen
CA, US
IPC
A61K 31/444
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