06450994 is referenced by 79 patents.

Apparatus for multi-dose delivery of preservative-free pharmaceuticals includes a film laminate flexible container for holding and maintaining a sterile drug formulation. A nozzle disposed within the container and in fluid communication therewith provides for dropwise dispensing of the formulation from the flexible container. The nozzle includes an interface established by inner and outer portions of the nozzle which is normally sealed. The nozzle out of portion is sufficiently flexible to enable expansion thereof and passage of the dry formulation therethrough by a piston which withdraws selected volumes of the formulation from the container.

Title
Storage and delivery of multi-dose, preservative-free pharmaceuticals
Application Number
9/526052
Publication Number
6450994 (B1)
Application Date
March 15, 2000
Publication Date
September 17, 2002
Inventor
John S Kent
Newport Coast
CA, US
James V C Boyles
San Diego
CA, US
Agent
Walter A Hackler
US
Assignee
Allergan
CA, US
IPC
A61M 35/00
View Original Source