06447752 is referenced by 15 patents and cites 14 patents.

Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm

3

/. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, porous particles having a relatively large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The porous particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

Title
Amorphous porous particles for deep lung delivery
Application Number
9/888781
Publication Number
6447752 (B2)
Application Date
June 25, 2001
Publication Date
September 10, 2002
Inventor
Abdellaziz Ben Jebria
State College
PA, US
Robert S Langer
Newton
MA, US
Justin Hanes
Baltimore
MD, US
Noah Lotan
Haifa
US
Jeffrey S Hrkach
Cambridge
MA, US
Giovanni Caponetti
Somerville
MA, US
David A Edwards
Boston
MA, US
Agent
Hamilton Brook Smith & Reynolds P C
US
Assignee
Massachusetts Institute of Technology
MA, US
The Penn State Research Foundation
PA, US
IPC
A61K 9/12
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