06425867 is referenced by 461 patents.

Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.

Title
Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy
Application Number
9/397471
Publication Number
6425867 (B1)
Application Date
September 17, 1999
Publication Date
July 30, 2002
Inventor
Lawrence A Crum
Bellevue
WA, US
Victor Y Fujimoto
Seattle
WA, US
George W Keilman
Woodinville
WA, US
Stephen J Carter
La Conner
WA, US
Roy W Martin
Redmond
WA, US
Shahram Vaezy
Seattle
WA, US
Agent
Ronald M Anderson
US
Assignee
University of Washington
WA, US
IPC
A61B 8/00
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