06416740 is referenced by 165 patents and cites 92 patents.

The present invention is directed to targeted therapeutic delivery systems comprising a gas or gaseous precursor filled microsphere wherein said gas or gaseous precursor filled microsphere comprises an oil, a surfactant, and a therapeutic compound. Methods of preparing the targeted therapeutic delivery systems are also embodied by the present invention which comprise processing a solution comprising an oil and a surfactant in the presence of a gaseous precursor, at a temperature below the gel to liquid crystalline phase transition temperature of the surfactant to form gas or gaseous precursor filled microsphere, and adding to said microspheres a therapeutic compound resulting in a targeted therapeutic delivery system, wherein said processing is selected from the group consisting of controlled agitation, controlled drying, and a combination thereof.

Title
Acoustically active drug delivery systems
Application Number
9/75343
Publication Number
6416740 (B1)
Application Date
May 11, 1998
Publication Date
July 9, 2002
Inventor
Evan C Unger
Tucson
AZ, US
Agent
Woodcock Washburn
US
Assignee
Bristol Myers Squibb Medical Imaging
NJ, US
IPC
A61B 8/00
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