06413750 is referenced by 41 patents.

In a method for improving the NADH specificity of preferred NADPH-dependent dehydrogenases, the alkalinity of the enzyme is reduced in the coenzyme docking area by an appropriate change of the amino acid sequence achieved by genetic engineering means. The inventive process is especially used for obtaining short-chain dehydrogenases with coenzyme binding areas on the N-terminus from

Lactobacillus brevis

and

Lactobacillus kefir.

Title
(R)-specific alcohol dehydrogenases from lactobacillus with improved catalytic activity using an NAD+ substrate
Application Number
9/447125
Publication Number
6413750 (B1)
Application Date
November 18, 1999
Publication Date
July 2, 2002
Inventor
Bettina Riebel
Frankfurt
US
Werner Hummel
Titz
US
Agent
Klaus J Bach
US
Assignee
Forschungszentrum J├╝lich
US
IPC
C12N 9/04
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