06410729 is referenced by 21 patents and cites 23 patents.

Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Title
Substituted pyrimidine compounds and methods of use
Application Number
9/598740
Publication Number
6410729 (B1)
Application Date
June 21, 2000
Publication Date
June 25, 2002
Inventor
Nathan B Mantlo
Lafayette
CO, US
Michael J Malone
Boulder
CO, US
Ulrike D Spohr
Boulder
CO, US
Agent
Stuart L Watt
US
Frank S Ungemach
US
Assignee
Amgen
CA, US
IPC
C07D 239/02
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