06399369 is referenced by 16 patents and cites 6 patents.

cDNA libraries may be obtained from neural cell cultures produced by using growth factors to induce the proliferation of multipotent neural stem cells. The libraries may be obtained from both cultured normal and dysfunctional neural cells and from neural cell cultures at various stages of development. This information allows for the identification of the sequence of gene expression during neural development and can be used to reveal the effects of biological agents on gene expression in neural cells. Additionally, nucleic acid derived from dysfunctional tissue can be compared with that of normal tissue to identify genetic material which may be a cause of the dysfunction. This information could then be used in the design of therapies to treat the neurological disorder. A further use of the technology would be in the diagnosis of genetic disorders or for use in identifying neural cells at a particular stage in development.

Title
Multipotent neural stem cell cDNA libraries
Application Number
8/484203
Publication Number
6399369 (B1)
Application Date
June 7, 1995
Publication Date
June 4, 2002
Inventor
Brent Reynolds
Saltspring
US
Samuel Weiss
Calgary
US
Agent
Mintz Levin Cohn Ferris Glovsky and Popeo PC
US
Agent
Christina V Karnakis Esq
US
Ivor R Elrifi Esquire
US
Assignee
Neurospheres Holdings
US
IPC
C12N 15/66
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