06395705 is referenced by 61 patents.

This invention relates to a method for treating a subject with irritable bowel syndrome (“IBS”) which comprises long-term administration of an opioid receptor antagonist at an appropriately low dose which will selectively antagonize excitatory opioid receptor functions, but not inhibitory opioid receptor functions, in myenteric neurons in the intestinal tract as well as in neurons of the central nervous system (“CNS”). The administration of the opioid receptor antagonist at a low dose enhances the potency of the inhibitory effects of endogenous opioid peptides present in the intestinal tract and the CNS, thereby reducing abdominal pain and stool frequency resulting from abnormally supersensitized excitatory opioid receptor functions. The invention also relates to a composition for treating a subject with IBS, which comprises an effective dose of an opioid receptor antagonist, and a pharmaceutically acceptable carrier.

Title
Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists
Application Number
9/754840
Publication Number
6395705 (B2)
Application Date
January 4, 2001
Publication Date
May 28, 2002
Inventor
Gerald M Fleischner
Chappaqua
NY, US
Ke fei Shen
Flushing
NY, US
Stanley M Crain
Leonia
NJ, US
Agent
Amster Rothstein & Ebenstein
US
Assignee
Albert Einstein College of Medicine of Yeshiva University
NY, US
IPC
A61K 38/00
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