06365362 is referenced by 162 patents and cites 3 patents.

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater sensitivity than conventional PCR or immunohistochemistry by 1-2 orders of magnitude. In addition, the assay facilitates the biological characterization and staging of carcinoma cells.

Title
Methods and reagents for the rapid and efficient isolation of circulating cancer cells
Application Number
9/248388
Publication Number
6365362 (B1)
Application Date
February 12, 1999
Publication Date
April 2, 2002
Inventor
Paul A Liberti
Huntingdon Valley
PA, US
Emilian V Racila
Dallas
TX, US
Jonathan W Uhr
Dallas
TX, US
Galla Chandra Rao
Princeton
NJ, US
Leon W M M Terstappen
Huntingdon Valley
PA, US
Agent
Dann Dorfman Herrell and Skillman
US
Assignee
Board of Regents The University of Texas System
TX, US
Immunivest Corporation
DE, US
IPC
G01N 33/574
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