06348587 is referenced by 116 patents and cites 10 patents.

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae:

wherein

Base is a purine or pyrimidine base; R

1

is OH, H, OR

3

, N

3

, CN, halogen, including F, or CF

3

, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy, and base refers to a purine or pyrimidine base;

R

2

is H, phosphate, including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of providing a compound wherein R

2

is H or phosphate; sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl, benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given above, a lipid, an amino acid, peptide, or cholesterol; and

R

3

is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of being cleaved to the parent compound, or a pharmaceutically acceptable salt thereof.

Title
2′-Fluoronucleosides
Application Number
9/257130
Publication Number
6348587 (B1)
Application Date
February 25, 1999
Publication Date
February 19, 2002
Inventor
Joon H Hong
Athens
GA, US
Kyeong Lee
Athens
GA, US
Yongseok Choi
Athens
GA, US
Junxing Shi
Decatur
GA, US
J Jeffrey McAtee
Atlanta
GA, US
Chung K Chu
Athens
GA, US
Dennis C Liotta
McDonough
GA, US
Raymond F Schinazi
Decatur
GA, US
Agent
King & Spalding
US
Agent
Josephine Young
US
Sherry M Knowles Esq
US
Assignee
University of Georgia Research Foundation
GA, US
Emory University
GA, US
IPC
C07H 21/02
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