06348474 is referenced by 57 patents and cites 10 patents.

A sulfonamide compound of the formula (I):

R

1

—SO

2

NHCO—A—R

2

  (I)

wherein R

1

is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R

2

is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.

Title
Sulfonamide compounds and medicinal use thereof
Application Number
9/446110
Publication Number
6348474 (B1)
Application Date
February 14, 2000
Publication Date
February 19, 2002
Inventor
Takafumi Imoto
Arai
US
Takahiro Hiramura
Arai
US
Masahiro Nishikawa
Arai
US
Osamu Onomura
Nagasaki
US
Noritsugu Yamasaki
Himeji
US
Teruo Oku
Takatsuki
US
Tsuyoshi Mizutani
Tsukuba
US
Hitoshi Sawada
Tsukuba
US
Hitoshi Hamashima
Kyoto
US
Yoshito Abe
Tsukuba
US
Hiroshi Kayakiri
Suita
US
Agent
Oblon Spivak McClelland Maier & Neustadt P C
US
Assignee
Fujisawa Pharmaceutical
US
IPC
A61K 31/435
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