06344354 is referenced by 40 patents.

The invention provides replication of high growth influenza virus strains, derived from clinical isolates, in cultured mammalian cells by infecting the mammalian cells with the high growth strains to obtain infected cells, and culturing the cells while maintaining a trypsin concentration range of 0.05-1.0 &mgr;g/ml in the culture medium, where the resulting replicated virus is suitable for use in mammalian influenza vaccines and vaccination methods, which are also provided by the invention.

Title
Influenza virus replicated in mammalian cell culture and vaccine production
Application Number
9/97712
Publication Number
6344354 (B1)
Application Date
June 16, 1998
Publication Date
February 5, 2002
Inventor
Nicolai V Kaverin
Moscow
US
Robert G Webster
Memphis
TN, US
Agent
Sterne Kessler Goldstein & Fox P L L C
US
Assignee
St Jude Children&apos s Research Hospital
TN, US
IPC
C12N 7/00
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