06334856 is referenced by 605 patents and cites 13 patents.

Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

Title
Microneedle devices and methods of manufacture and use thereof
Application Number
9/316229
Publication Number
6334856 (B1)
Application Date
May 21, 1999
Publication Date
January 1, 2002
Inventor
Florent Paul Marcel Cros
Atlanta
GA, US
Devin V McAllister
Holley
NY, US
Mark R Prausnitz
Decatur
GA, US
Mark G Allen
Atlanta
GA, US
Agent
Sutherland Asbill & Brennan
US
Assignee
Georgia Tech Research Corporation
GA, US
IPC
A61M 5/00
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