06333180 is referenced by 22 patents and cites 4 patents.

Described is a bioprocess for the high-yield production of food flavor-acceptable jasmonic acid and methyl jasmonate, as well as a novel jasmonic acid isomer produced thereby and organoleptic uses thereof. The process yields at least 5% of the “cis” isomer defined according the structure:

(wherein R is hydrogen or methyl) or at least 5% of the “cis” isomer defined according to the structure:

(wherein R is hydrogen or methyl). Compositions containing at least 98% of the isomer having the structure:

with an optical rotation (&agr;

D

20

) of +58° are novel. Compositions containing at least 98% of the isomer having the structure:

with an optical rotation (&agr;

D

20

) of +58° are also novel. The process of our invention comprises the cultivation under aerobic condition of one or more specific strain of

Diplodia gossypina

in a nutrient medium followed either by (1) isolation of the jasmonic acid product or (2) esterification of the jasmonic acid to form methyl jasmonate followed by the isolation of the methyl jasmonate and novel products produced by such process.

Title
Bioprocess for the high-yield production of food flavor-acceptable jasmonic acid and methyl jasmonate
Application Number
9/468134
Publication Number
6333180 (B1)
Application Date
December 21, 1999
Publication Date
December 25, 2001
Inventor
Myrna Hagedorn
Woodland Park
CO, US
Augustine Yonghwi Kim
Morganville
NJ, US
Nicolas Kossiakoff
Les Arcs sur Argens
US
Michael P McLean
Matawan
NJ, US
Mark A Sprecker
Sea Bright
NJ, US
Lynda B McLean
Matawan
NJ, US
Robert W Blocker
Brick
NJ, US
Mohamad I Farbood
State College
PA, US
Agent
Joseph P Leightner
US
Assignee
International Flavors & Fragrances
NY, US
IPC
C12P 17/02
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