06329161 is referenced by 1054 patents and cites 307 patents.

A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucoses is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

Title
Subcutaneous glucose electrode
Application Number
9/668221
Publication Number
6329161 (B1)
Application Date
September 22, 2000
Publication Date
December 11, 2001
Inventor
Michael V Pishko
Austin
TX, US
Adam Heller
Austin
TX, US
Agent
Merchant & Gould P C
US
Assignee
TheraSense
CA, US
IPC
C12Q 1/54
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