06323278 is referenced by 102 patents and cites 149 patents.

Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH

2

) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

Title
Method of making crosslinked polymer matrices in tissue treatment applications
Application Number
9/733739
Publication Number
6323278 (B2)
Application Date
December 8, 2000
Publication Date
November 27, 2001
Inventor
Richard A Berg
Los Altos
CA, US
Frank A DeLustro
Belmont
CA, US
Woonza M Rhee
Palo Alto
CA, US
Agent
Dianne E Reed
US
Laurie A Axford
US
Assignee
Cohesion Technologies
CA, US
IPC
C08F 283/00
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