06316022 is referenced by 64 patents and cites 63 patents.

A transdermal composition is disclosed which contains a blend of one or more polymers, one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures. The composition is substantially free of water and liquids which have a normal boiling point (a) optionally below processing temperatures and (b) greater than or equal to the temperature of the low molecular weight drugs. The composition does not suffer from the substantial loss of the lower molecular weight drug during production of the transdermal system. A transdermal composition is also disclosed which has one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures, and a polymer matrix including one or more high shear resistant polymers. The high shear resistant polymer(s) reduce the plasticizing effect of the low molecular weight drug, and has sufficient tack and shear for application to a human being.

Title
Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
Application Number
8/578308
Publication Number
6316022 (B1)
Application Date
December 26, 1995
Publication Date
November 13, 2001
Inventor
David Houze
Coconut Grove
FL, US
Juan Mantelle
Miami
FL, US
Agent
Foley & Lardner
US
Assignee
Noven Pharmaceuticals
FL, US
IPC
A61K 9/70
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