06314325 is referenced by 245 patents and cites 22 patents.

Methods and apparatus are disclosed for hyperpolarizing the medial branch of the spinal nerve associated with a painful spinal facet joint so as to block pain impulses from reaching the spinal cord. The preferred apparatus includes a neurostimulator and two or more electrodes which carry electrical pulses to the target nerve or nerves. The impulses are intense enough to cause hyperpolarization of a given medial branch and its articular branches, but not so large as to spread to the spinal cord itself. In the preferred embodiment the stimulator is physically small and battery operated, facilitating implantation underneath the skin. The stimulator includes a controller and appropriate electronics operative to generate electrical impulses tailored to an individual's need for appropriate pain relief in terms of pulse frequency, pulse width, and pulse amplitude. In an alternative embodiment, the stimulator further includes electrodes and electrical circuitry operative to monitor myoelectrical activity generated by the surrounding muscles and modulate the impulses generated by the stimulator to meet the demands of the individual's activity and/or prolong battery life.

Title
Nerve hyperpolarization method and apparatus for pain relief
Application Number
9/336241
Publication Number
6314325 (B1)
Application Date
June 18, 1999
Publication Date
November 6, 2001
Inventor
William R Fitz
6500 Mariemont Ave., Cincinnati
OH, US
Agent
Gifford Krass Groh Sprinkle Anderson & Citkowski PC
US
IPC
A61N 1/34
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