06312612 is referenced by 298 patents and cites 41 patents.

A microneedle array is constructed of silicon and silicon dioxide compounds using MEMS (i.e., Micro-Electro-Mechanical-Systems) technology and standard microfabrication techniques. The microneedle array may be fabricated from a silicon die which can be etched in a microfabrication process to create hollow cylindrical individual microneedles. The resulting array of microneedles can penetrate with a small pressure through the stratum corneum of skin (including skin of animals, reptiles, or other creatures—typically skin of a living organism) to either deliver drugs or to facilitate interstitial fluid sampling through the hollow microneedles.

Title
Apparatus and method for manufacturing an intracutaneous microneedle array
Application Number
9/328946
Publication Number
6312612 (B1)
Application Date
June 9, 1999
Publication Date
November 6, 2001
Inventor
Grover David Owens
Fairfield
OH, US
Vladimir Gartstein
Cincinnati
OH, US
Vadim Vladimirovich Yuzhakov
Cincinnati
OH, US
Faiz Feisal Sherman
Cincinnati
OH, US
Agent
Bart S Hersko
US
Assignee
The Procter & Gamble Company
OH, US
IPC
B81C 1/00
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