06309669 is referenced by 195 patents and cites 14 patents.

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group and end-capped forms ranging in ratios from 100/0 to 1/99.

Title
Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
Application Number
8/789734
Publication Number
6309669 (B1)
Application Date
January 27, 1997
Publication Date
October 30, 2001
Inventor
Phil Friden
Beford
MA, US
F Donald Roberts
Dover
MA, US
Thomas R Tice
Birmington
AL, US
Curt Thies
Ballwin
MO, US
William Brown
Denver
CO, US
Frederick Cassels
Ellicott City
MD, US
Daniel L Jarboe
Silver Spring
MD, US
Charles E McQueen
Olney
MD, US
Edgar C Boedeker
Chevy Chase
MD, US
Ramasubbu Jeyanthi
Columbia
MD, US
Elliot Jacob
Silver Spring
MD, US
Robert H Reid
McComas
CT, US
John E Van Hamont
Fort Meade
MD, US
Jean A Setterstrom
Alpharetta
GA, US
Agent
Elizabeth Arwine
US
Caroline Nash
US
Assignee
The United States of America represented by the Secretary of the Army
DC, US
IPC
A61K 9/52
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