06299757 is referenced by 621 patents and cites 342 patents.

A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

Title
Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
Application Number
9/413565
Publication Number
6299757 (B1)
Application Date
October 6, 1999
Publication Date
October 9, 2001
Inventor
Rajesh Krishnan
Fremont
CA, US
Fredric C Colman
Oakland
CA, US
Jeffery V Funderburk
Fremont
CA, US
Joseph A Vivolo
San Francisco
CA, US
Fei Mao
Fremont
CA, US
Ephraim Heller
Oakland
CA, US
Adam Heller
Austin
TX, US
Benjamin J Feldman
Oakland
CA, US
Agent
Merchant & Gould P C
US
Assignee
TheraSense
CA, US
IPC
G01N 27/26
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