06297018 is referenced by 150 patents and cites 373 patents.

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance energy transfer (FRET) detection, and (3) allele-specific nucleotide incorporation, using primer extension with luminescence polarization (FP) detection. More specifically, the methods may include (1) locating a sample containing a nucleic acid material at an examination site, (2) illuminating the sample, (3) detecting light transmitted from the sample, and (4) determining the presence, absence, and/or identity of a nucleic acid target in the sample using the light transmitted from the sample.

Title
Methods and apparatus for detecting nucleic acid polymorphisms
Application Number
9/494407
Publication Number
6297018 (B1)
Application Date
January 28, 2000
Publication Date
October 2, 2001
Inventor
Enal S Razvi
San Francisco
CA, US
Lev J Leytes
Palo Alto
CA, US
James S Richey
Palo Alto
CA, US
John C Owicki
Palo Alto
CA, US
Douglas N Modlin
Palo Alto
CA, US
Todd E French
Cupertino
CA, US
Agent
Kolisch Hartwell Dickinson McCormack & Heuser
US
Assignee
LJL BioSystems
CA, US
IPC
C02Q 1/68
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