06287516 is referenced by 131 patents and cites 32 patents.

A hemofiltration system for a mammal comprises a hemofilter and an adsorbent device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorbent device is comprised of one or more adsorbent materials and is used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter removing inflammatory mediators that cause inflammatory mediator related disease, sepsis, and SIRS/MODS/MOSF to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream is selectively combined with the filtered blood stream and together with the filtered blood stream is returned to the mammal. A hemofiltration process for a mammal is comprised of the following steps: (a) removing blood from the mammal to create a blood stream; (b) filtering the blood stream to remove ultrafiltrate from the blood to create an ultrafiltrate stream and a filtered blood stream; (c) adsorption of the inflammatory mediators from the ultrafiltrate stream that cause inflammatory mediator related disease, sepsis, SIRS/MODS/MOSF to create a post adsorption ultrafiltrate stream; (d) combining the post adsorption ultrafiltrate stream with the filtered blood stream to create a post adsorption ultrafiltrate/filtered blood stream; and (e) returning the post adsorption ultrafiltrate/filtered blood stream to the mammal.

Title
Hemofiltration systems, methods, and devices used to treat inflammatory mediator related disease
Application Number
9/113758
Publication Number
6287516 (B1)
Application Date
July 10, 1998
Publication Date
September 11, 2001
Inventor
Patrice R Lee
Erie
CO, US
James R Matson
Dallas
TX, US
Agent
Baker Botts L
US
Assignee
Immunocept L L C
TX, US
IPC
A61M 1/14
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