06287285 is referenced by 190 patents and cites 123 patents.

A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.

Title
Therapeutic, diagnostic, or hydrophilic coating for an intracorporeal medical device
Application Number
9/240914
Publication Number
6287285 (B1)
Application Date
January 29, 1999
Publication Date
September 11, 2001
Inventor
Stephen J Bigus
San Jose
CA, US
Christopher J Buchko
San Francisco
CA, US
Eugene T Michal
San Francisco
CA, US
Agent
Heller Ehrman White & McAuliffe
US
Assignee
Advanced Cardiovascular Systems
CA, US
IPC
A61M 5/00
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