06284478 is referenced by 865 patents and cites 306 patents.

A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

Title
Subcutaneous glucose electrode
Application Number
8/767110
Publication Number
6284478 (B1)
Application Date
December 4, 1996
Publication Date
September 4, 2001
Inventor
Michael V Pishko
Austin
TX, US
Adam Heller
Austin
TX, US
Agent
Merchant & Gould P C
US
Assignee
E Heller & Company
CA, US
IPC
C12Q 1/54
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